FITC标记的钠钙交换蛋白1抗体
产品名称： FITC标记的钠钙交换蛋白1抗体
英文名称： Anti-NCX1/FITC
产品编号： HZ-1550R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
- 联系人 : 鲍丽雯
- 地址 : 上海市闵行区闵北路88弄1-30号第22幢AQ136室
- 邮编 : 200612
- 所在区域 : 上海
- 电话 : 139****0749 点击查看
- 传真 : 点击查看
- 邮箱 : www.shzbio.net
- 二维码 : 点击查看
Rabbit Anti-NCX1/FITC Conjugated antibody
FITC标记的钠钙交换蛋白1抗体
| 英文名称 | Anti-NCX1/FITC |
| 中文名称 | FITC标记的钠钙交换蛋白1抗体 |
| 别 名 | Na+/Ca2+exchanger 1; CNC; DKFZp779F0871; MGC119581; FLJ37694; FLJ43417; Na+/Ca2+ exchange protein 1; Na+/Ca2+ exchanger; NCX 1; NCX; SLC8A1; SLC8A1 protein; Sodium Calcium Exchanger; Sodium/calcium exchanger 1; Solute carrier family 8 member 1; NAC1_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 免疫学 转运蛋白 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Sheep, Guinea Pig, G |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 106kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human NCX1 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: In cardiac myocytes, Ca(2+) concentrations alternate between high levels during contraction and low levels during relaxation. The increase in Ca(2+) concentration during contraction is primarily due to release of Ca(2+) from intracellular stores. However, some Ca(2+) also enters the cell through the sarcolemma(plasma membrane). During relaxation, Ca(2+) is sequestered within the intracellular stores. To prevent overloading of intracellular stores, the Ca(2+) that entered across the sarcolemma must be extruded from the cell. The Na(+)-Ca(2+) exchanger is the primary mechanism by which the Ca(2+) is extruded from the cell during relaxation. In the heart, the exchanger may play a key role in digitalis action. The exchanger is the dominant mechanism in returning the cardiac myocyte to its resting state following excitation.[supplied by OMIM]. Subcellular Location: Cell membrane. Tissue Specificity: Expressed in cardiac sarcolemma, brain, kidney, liver, pancreas, skeletal muscle, placenta and lung. Similarity: Belongs to the sodium/potassium/calcium exchanger family. SLC8 subfamily. Contains 2 Calx-beta domains. Database links: Entrez Gene: 6546 Human Entrez Gene: 20541 Mouse Entrez Gene: 100328570 Rabbit Entrez Gene: 29715 Rat Omim: 182305 Human SwissProt: P23685 Dog SwissProt: P48766 Guinea pig SwissProt: P32418 Human SwissProt: P70414 Mouse SwissProt: Q01728 Rat Unigene: 31961 Human Unigene: 468274 Human Unigene: 728911 Human Unigene: 265834 Mouse Unigene: 118972 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
在心肌细胞中，Ca（2 +）浓度在收缩过程中处于高水平，舒张过程中处于低水平。Ca（2＋）浓度在收缩过程中的增加主要是由于胞内贮存物释放Ca（2 +）所致。然而，一些钙（2 +）也通过肌膜（细胞膜）进入细胞。在放松过程中，Ca（2 +）被隔离在细胞内储存。为了防止细胞内储存物的超载，进入肌膜的CA（2 +）必须从细胞中挤出。钠（+）-Ca（2＋）交换器是Ca（2＋）在细胞松弛过程中从细胞中挤出的主要机制。在心脏中，交换器可能在洋地黄作用中起关键作用。交换器是使心肌细胞在兴奋后恢复到静止状态的主要机制。