FITC标记的环磷酸腺苷反应元件调节蛋白抗体
产品名称： FITC标记的环磷酸腺苷反应元件调节蛋白抗体
英文名称： Anti-CREM/FITC
产品编号： HZ-5135R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-CREM/FITC Conjugated antibody
FITC标记的环磷酸腺苷反应元件调节蛋白抗体
| 英文名称 | Anti-CREM/FITC |
| 中文名称 | FITC标记的环磷酸腺苷反应元件调节蛋白抗体 |
| 别 名 | cAMP response element modulator; CREM-1; cAMP responsive element modulator; hCREM 2; hCREM2; ICER; Inducible cAMP early repressor; Inducible cAMP early repressor ICER; MGC111110; MGC17881; MGC41893. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 免疫学 转录调节因子 激酶和磷酸酶 结合蛋白 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Pig, Horse, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 40kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CREM |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: CREM is a a bZIP transcription factor that binds to the cAMP responsive element found in many viral and cellular promoters. It is derived from a multiexonic gene that encodes both activators and antagonists of cAMP-inducible transcription by differential splicing. Splice variants with antagonistic function lack 2 glutamine-rich domains and block cAMP-induced transcription, whereas an isoform that includes these glutamine-rich domains is a transcriptional activator. Function: Transcriptional regulator that binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. Isoforms are either transcriptional activators or repressors. Plays a role in spermatogenesis and is involved in spermatid maturation (By similarity). Subunit: Binds DNA as a dimer. Interacts with FHL5. Interacts with CDC34. Subcellular Location: Nucleus. Tissue Specificity: Expressed in testes (round spermatids) (at protein level). Isoform 14 is the major activator form in testes. Post-translational modifications: Isoform 9 is ubiquitinated by CDC34 and RAD6B in order to be degraded by the proteasome. Stimulated by phosphorylation. Similarity: Belongs to the bZIP family. Contains 1 bZIP domain. Contains 1 KID (kinase-inducible) domain. Database links: Entrez Gene: 1390 Human Entrez Gene: 12916 Mouse Entrez Gene: 25620 Rat Omim: 123812 Human SwissProt: Q03060 Human SwissProt: P27699 Mouse SwissProt: Q03061 Rat Unigene: 200250 Human Unigene: 5244 Mouse Unigene: 10251 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. CREM是一种与CREB高度同源的蛋白，与CREB均一表达于几种细胞类型不同，其表达具有细胞特异性,CREM同CREB一样能高效特异性结合到CRE元件上，但相反的是其下调cAMP诱导的转录 |
CREM是一种结合在许多病毒和细胞启动子中的cAMP应答元件的BZIP转录因子。它来源于一个多外显子基因，它通过差异剪接编码cAMP诱导转录的激活剂和拮抗剂。具有拮抗功能的剪接变异体缺乏2个富含谷氨酰胺结构域和阻断cAMP诱导的转录，而包含这些富含谷氨酰胺结构域的异构体是转录激活剂。