STK4 polyclonal antibody
产品名称： STK4 polyclonal antibody
英文名称： STK4 polyclonal antibody
产品编号： PAB2831
产品价格： null
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围：
亚诺法生技股份有限公司（Abnova)
- 联系人 :
- 地址 : 台湾台北市内湖区洲子街 108 号 9 楼
- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of STK4.
- Immunogen:
- A synthetic peptide (conjugated with KLH) corresponding to N-terminus of human STK4.
- Host:
- Rabbit
- Reactivity:
- Human
- Form:
- Liquid
- Purification:
- Protein A purification
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000)
Western Blot (1:50-100)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Frequent hypermethylation of MST1 and MST2 in soft tissue sarcoma.
Seidel C, Schagdarsurengin U, Blumke K, Wurl P, Pfeifer GP, Hauptmann S, Taubert H, Dammann R.Mol Carcinog. 2007 Oct;46(10):865-71.
- 2.
- The pro-apoptotic kinase Mst1 and its caspase cleavage products are direct inhibitors of Akt1.
Cinar B, Fang PK, Lutchman M, Di Vizio D, Adam RM, Pavlova N, Rubin MA, Yelick PC, Freeman MR.EMBO J. 2007 Oct 31;26(21):4523-34. Epub 2007 Oct 11.
- 3.
- Akt phosphorylates MstI and prevents its proteolytic activation, blocking FOXO3 phosphorylation and nuclear translocation.
Jang SW, Yang SJ, Srinivasan S, Ye K.J Biol Chem. 2007 Oct 19;282(42):30836-44. Epub 2007 Aug 28.
- Applications
- Western Blot (Cell lysate)
- Western blot analysis of STK4 polyclonal antibody (Cat # PAB2831) in Jurkat cell line lysates (35 ug/lane). STK4 (arrow) was detected using the purified polyclonal antibody (1 : 60 dilution).
- Entrez GeneID:
- 6789
- Protein Accession#:
- NP_006273;Q13043
- Gene Name:
- STK4
- Gene Alias:
- DKFZp686A2068,KRS2,MST1,YSK3
- Gene Description:
- serine/threonine kinase 4
- Omim ID:
- 604965
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene is a cytoplasmic kinase that is structurally similar to the yeast Ste20p kinase, which acts upstream of the stress-induced mitogen-activated protein kinase cascade. The encoded protein can phosphorylate myelin basic protein and undergoes autophosphorylation. A caspase-cleaved fragment of the encoded protein has been shown to be capable of phosphorylating histone H2B. The particular phosphorylation catalyzed by this protein has been correlated with apoptosis, and it's possible that this protein induces the chromatin condensation observed in this process. [provided by RefSeq
- Other Designations:
- OTTHUMP00000043418,dJ211D12.2 (serine/threonine kinase 4 (MST1, KRS2)),kinase responsive to stress 2,mammalian sterile 20-like 1,yeast Ste20-like
- Related Disease