GRK4 (C-term) Peptide
产品名称： GRK4 (C-term) Peptide
英文名称： GRK4 (C-term) Peptide
产品编号： P2089
产品价格： 0
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围： null
亚诺法生技股份有限公司（Abnova)
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- 邮编 : 11493
- 所在区域 : 台湾
- 电话 : +886-920**1152 点击查看
- 传真 : 点击查看
- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of GRK4.
- Immunogen:
- A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human GRK4.
- Host:
- Rabbit
- Reactivity:
- Human
- Form:
- Liquid
- Purification:
- Protein G purification
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000)
Western Blot (1:100-500)
Immunohistochemistry (1:10-50)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Phosphorylation-independent desensitization of GABA(B) receptor by GRK4.
Perroy J, Adam L, Qanbar R, Chenier S, Bouvier M.EMBO J. 2003 Aug 1;22(15):3816-24.
- 2.
- Desensitization of human renal D1 dopamine receptors by G protein-coupled receptor kinase 4.
Watanabe H, Xu J, Bengra C, Jose PA, Felder RA.Kidney Int. 2002 Sep;62(3):790-8.
- 3.
- G protein-coupled receptor kinase GRK4. Molecular analysis of the four isoforms and ultrastructural localization in spermatozoa and germinal cells.
Sallese M, Mariggio S, Collodel G, Moretti E, Piomboni P, Baccetti B, De Blasi A.J Biol Chem. 1997 Apr 11;272(15):10188-95.
- Applications
- Western Blot (Cell lysate)
- Western blot analysis of GRK4 polyclonal antibody (Cat # PAB4518) in HL-60 cell lysate . GRK4 (arrow) was detected using purified GRK4 polyclonal antibody (Cat # PAB4518) . Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence .
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- Formalin-fixed and paraffin-embedded human testis tissue reacted with GRK4 polyclonal antibody (Cat # PAB4518) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining . This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated .
- Entrez GeneID:
- 2868
- Protein Accession#:
- P32298
- Gene Name:
- GRK4
- Gene Alias:
- GPRK2L,GPRK4,GRK4a,IT11
- Gene Description:
- G protein-coupled receptor kinase 4
- Omim ID:
- 137026
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating its deactivation. This gene has been linked to both genetic and acquired hypertension. [provided by RefSeq
- Other Designations:
- G protein-coupled receptor kinase 2-like,G-protein coupled receptor kinase 4
- Gene Pathway
- Related Disease
- Asthma
- Asthma
- Atherosclerosis
- Calcinosis
- Cardiovascular Diseases
- Coronary Artery Disease
- Diabetes Mellitus
- Diabetes Mellitus, Type 2
- Edema
- Genetic Predisposition to Disease
- Hyperparathyroidism, Secondary
- Hypertension
- Hypertension, Renal
- Hypertrophy, Left Ventricular
- Kidney Failure, Chronic
- Pre-Eclampsia
- Tachycardia