NR5A1 抗体-第二抗体-抗体-生物在线
上海信裕生物科技有限公司
NR5A1 抗体

NR5A1 抗体

商家询价

产品名称： NR5A1 抗体

英文名称： NR5A1 Antibody

产品编号： XY18658-1

产品价格： null

产品产地： 中国/美国

品牌商标： XYbscience

更新时间： 2023-08-17T09:55:27

使用范围： WB,ELISA,IHC-P,IHC-F,IF

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 NR5A1 抗体Applications

Tested Applications: ELISA, WB, IHC, IP
Specificity Reaction: Human,Mouse,Rat; Other species are not tested.Please decide the specificity by homology
Positive WB detected in Mouse ovary tissue
Positive IP detected in A2780 cells
Positive IHC detected in Human liver tissue, human ovary tissue
Recommended dilution WB : 1:500-1:5000
IP : 1:200-1:1000
IHC : 1:20-1:200
 NR5A1 抗体Application key: WB=Western Blotting ,IHC=Immunohistochemistry, IF=Immunofluorescence
Images
Prev12NextView more validation data
  • 18658-1-AP;mouse ovary tissuemouse ovary tissue were subjected to SDS PAGE followed by western blot with 18658-1-AP(NR5A1 antibody) at dilution of 1:1000
  • 18658-1-AP;human liverImmunohistochemical of paraffin-embedded human liver using 18658-1-AP(NR5A1 antibody) at dilution of 1:100 (under 10x lens)
  • 18658-1-AP;human liverImmunohistochemical of paraffin-embedded human liver using 18658-1-AP(NR5A1 antibody) at dilution of 1:100 (under 40x lens)
  • 18658-1-AP;A2780 cellsIP Result of anti-NR5A1 (IP:18658-1-AP, 4ug; Detection:18658-1-AP 1:300) with A2780 cells lysate 960ug.
Product Information
Source: Rabbit Purify: Antigen affinity purification
IsoType: IgG Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3. -20oC, Avoid freeze / thaw cycles.
Immunogen Information NR5A1 抗体
Immunogen: NR5A1 fusion protein ag13252 Full Name: Nuclear receptor subfamily 5, group A, member 1
Caculated Molecular
Weight:		 52 kDa Observed Molecular 
Weight:		 53 kDa
GenbankNo BC032501 GeneID: 2516
Symbol NR5A1 Synonyms AD4BP, Adrenal 4 binding protein, ELP, FTZ1, FTZF1, Fushi tarazu factor homolog 1, NR5A1, SF 1, SF1, SF-1, Steroid hormone receptor Ad4BP, Steroidogenic factor 1, STF 1
Background

Steroidogenic factor-1 (SF-1,STF-1), also known as NR5A1, regulates multiple genes involved in the adrenal and gonadal development and in the biosynthesis of a variety of hormones, including adrenal and gonadal steroids, anti-Mullerian hormone (AMH), and gonadotropins. SF-1 belongs to the fushi tarazu factor-1 (FTZ-F1) subfamily of orphan nuclear receptors. Initially identified as a tissue-specific transcriptional regulator of cytochrome P450 steroid hydroxylases, research studies of both global and tissue-specific knockout mice have demonstrated that SF-1 is required for the development of adrenal glands, gonads, ventromedial hypothalamus, and for the proper functioning of pituitary gonadotropes. Indeed, humans with mutations that render SF-1 transcriptionally inactive can present with testicular failure, ovarian failure, and adrenal insufficiency. Furthermore, dysregulation of SF-1 has been linked to diseases such as endometriosis and adrenocortical carcinoma.Like other nuclear hormone receptors, SF-1 has a modular domain structure composed of an N-terminal zinc finger DNA-binding domain, a ligand-binding domain, a C-terminal AF-2 activation domain, and a hinge region with AF-1-like activation activity. SF-1 also contains a fushi tarazu factor 1 box, which functions as an accessory DNA binding domain. SF-1 is primarily phosphorylated at Ser203, which is thought to enhance its transcriptional activity by promoting complex formation with transcriptional cofactors. In addition to phosphorylation at Ser203, SF-1 is subject to SUMO conjugation and acetylation at ε-amino groups of target lysine residues. Whereas SUMOylation represses SF-1 function, acetylation enhances its transcriptional activity.In the adult ovary, SF-1 localizes to theca/interstitial cells. NR5A1 抗体

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