MRE11A (Human) Recombinant Protein (P01)
产品名称: MRE11A (Human) Recombinant Protein (P01)
英文名称: MRE11A (Human) Recombinant Protein (P01)
产品编号: H00004361-P01
产品价格: 0
产品产地: 台湾
品牌商标: Abnova
更新时间: null
使用范围: null
亚诺法生技股份有限公司(Abnova)
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- Specification
- Product Description:
- Human MRE11A full-length ORF ( AAH05241, 1 a.a. - 206 a.a.) recombinant protein with GST-tag at N-terminal.
- Sequence:
- MSTADALDDENTFKILVATDIHLGFMEKDAVRGNDTFVTLDEILRLAQENEVDFILLGGDLFHENKPSRKTLHTCLELLRKYCMGDRPVQFEILSDQSVNFGFSKFPWVNYQDGNLNISIPVFSIHGNHDDPTGADALCALDILSCAGFVNHFGRSMSVEKIDISPVLLQKGRTKIALYGLGSIPDERLYRMFVNKKVTMLRPKED
- Theoretical MW (kDa):
- 48.4
- Preparation Method:
- in vitro wheat germ expression system
- Purification:
- Glutathione Sepharose 4 Fast Flow
- Storage Buffer:
- 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
- Storage Instruction:
- Store at -80°C. Aliquot to avoid repeated freezing and thawing.
- Quality Control Testing:
- 12.5% SDS-PAGE Stained with Coomassie Blue.
- Note:
- Best use within three months from the date of receipt of this protein.
- MSDS:
- Download
- Publication Reference
- 1.
- MRE11 facilitates the removal of human topoisomerase II complexes from genomic DNA.
Lee KC, Padget K, Curtis H, Cowell IG, Moiani D, Sondka Z, Morris NJ, Jackson GH, Cockell SJ, Tainer JA, Austin CA.Biology Open doi: 10.1242/ bio.20121834
- Application Image
- Enzyme-linked Immunoabsorbent Assay
- Western Blot (Recombinant protein)
- Antibody Production
- Protein Array
- Entrez GeneID:
- 4361
- GeneBank Accession#:
- BC005241
- Protein Accession#:
- AAH05241
- Gene Name:
- MRE11A
- Gene Alias:
- ATLD,HNGS1,MRE11,MRE11B
- Gene Description:
- MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq
- Other Designations:
- AT-like disease,DNA recombination and repair protein,double-strand break repair protein MRE11A,endo/exonuclease Mre11,meiotic recombination 11 homolog A
- Gene Pathway
- Related Disease
- Adenocarcinoma
- Ataxia Telangiectasia
- Ataxia telangiectasia
- Brain Neoplasms
- Breast cancer
- Breast Neoplasms
- Carcinoma, Ductal
- DNA Damage
- Genetic Predisposition to Disease
- Glioma
- Hematologic Diseases
- Hodgkin Disease
- Kidney Failure, Chronic
- Lymphoma, Non-Hodgkin
- Lymphoproliferative Disorders
- Multiple Sclerosis
- Neoplasms, Glandular and Epithelial
- Occupational Diseases
- Ovarian cancer