FITC标记的原钙粘蛋白γB5抗体
产品名称： FITC标记的原钙粘蛋白γB5抗体
英文名称： Anti-PCDHGB5/FITC
产品编号： HZ-5827R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-PCDHGB5/FITC Conjugated antibody
FITC标记的原钙粘蛋白γB5抗体
| 英文名称 | Anti-PCDHGB5/FITC |
| 中文名称 | FITC标记的原钙粘蛋白γB5抗体 |
| 别 名 | PCDH gamma B5; PCDHGB 5; Protocadherin gamma B5; Protocadherin gamma subfamily B 5; PCDGH_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 细胞生物 神经生物学 信号转导 细胞粘附分子 细胞表面分子 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 97kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human PCDHGB5 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: PCDHGB5 is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes. Function: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. Subcellular Location: Cell membrane; Single-pass type I membrane protein (By similarity). Similarity: Contains 6 cadherin domains. Database links: Entrez Gene: 56101 Human Omim: 606302 Human SwissProt: Q9Y5G0 Human SwissProt: Q9Y5G0-2 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic application |
PCDHGB5是原粘蛋白γ基因簇的成员，是与五号染色体连锁的三个相关簇之一。这些基因簇具有免疫球蛋白样组织，提示一种新的机制可能参与它们的调控和表达。Gamma基因簇包括22个基因，共分为3个亚科。亚科A包含12个基因，亚家族B包含7个基因和2个假基因，而更遥远的子家族C包含3个基因。22个大的可变区域外显子的串联阵列后面是一个恒定区域，包含3个基因簇中的所有外显子。每个可变区外显子编码胞外区，其中包括6个钙黏蛋白胞外域和跨膜区。恒定区外显子编码共同的细胞质区域。这些神经钙黏附素样细胞粘附蛋白最有可能在脑内特定细胞-细胞连接的建立和功能中起关键作用。已经描述了伽玛簇基因的选择性剪接。