MCM7 (Human) Recombinant Protein (P01)
产品名称： MCM7 (Human) Recombinant Protein (P01)
英文名称： MCM7 (Human) Recombinant Protein (P01)
产品编号： H00004176-P01
产品价格： 0
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围： null
亚诺法生技股份有限公司（Abnova)
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- Specification
- Product Description:
- Human MCM7 full-length ORF ( AAH09398, 1 a.a. - 389 a.a.) recombinant protein with GST-tag at N-terminal.
- Sequence:
- MALKDYALEKEKVKKFLQEFYQDDELGKKQFKYGNQLVRLAHREQVALYVDLDDVAEDDPELVDSICENARRYAKLFADAVQELLPQYKEREVVNKDVLDVYIEHRLMMEQRSRDPGMVRSPQNQYPAELMRRFELYFQGPSSSKPRVIREVRADSVGKLVTVRGIVTRVSEVKPKMVVATYTCDQCGAETYQPIQSPTFMPLIMCPSQECQTNRSGGRLYLQTRGSRFIKFQEMKMQEHSDQVPVGNIPRSITVLVEGENTRIAQPGDHVSVTGIFLPILRTGFRQVVQGLLSETYLEAHRIVKMNKSEDDESGAGELTREELRQIADVIFATVRELVSGGRSVRFSEAEQRCVSRGFTPAQFQAALDEYEELNVWQVNASRTRITFV
- Theoretical MW (kDa):
- 68.53
- Preparation Method:
- in vitro wheat germ expression system
- Purification:
- Glutathione Sepharose 4 Fast Flow
- Storage Buffer:
- 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
- Storage Instruction:
- Store at -80°C. Aliquot to avoid repeated freezing and thawing.
- Quality Control Testing:
- 12.5% SDS-PAGE Stained with Coomassie Blue.
- Note:
- Best use within three months from the date of receipt of this protein.
- MSDS:
Download
- Publication Reference
- 1.
- The selection and characterization of antibodies to minichromosome maintenance proteins that highlight cervical dysplasia.
Henderson D, Hall L, Prpic N, Hessling J, Parker M, Sampson S, Simkins S, Brough G, Dixon E, Lenz K, Knapp S, Murphy P, Taylor A, Fischer T, Malinowski DP.J Immunol Methods. 2011 May 12. [Epub ahead of print]
- Application Image
- Enzyme-linked Immunoabsorbent Assay
- Western Blot (Recombinant protein)
- Antibody Production
- Protein Array
- Entrez GeneID:
- 4176
- GeneBank Accession#:
- BC009398
- Protein Accession#:
- AAH09398
- Gene Name:
- MCM7
- Gene Alias:
- CDABP0042,CDC47,MCM2,P1.1-MCM3,P1CDC47,P85MCM,PNAS-146
- Gene Description:
- minichromosome maintenance complex component 7
- Omim ID:
- 600592
- Gene Ontology:
- Hyperlink
- Gene Summary:
- The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate with this protein, and may regulate the binding of this protein with the tumorsuppressor protein RB1/RB. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq
- Other Designations:
- DNA replication licensing factor MCM7,MCM7 minichromosome maintenance deficient 7,homolog of S. cerevisiae Cdc47,minichromosome maintenance deficient 7
- Interactome
- Gene Pathway
- Related Disease