慢性肾病(Chronic kidney disease，CKD)目前成为了一个主要的公共卫生问题，有越来越多的成年人患有CKD。多年来，针对这种疾病进行了大量研究，但仍需要改进治疗方法并识别和/或预测患者预后结果。已经确定在肾脏疾病中起重要作用的一种蛋白质是肾损伤分子-1 (KIM-1)。KIM-1是一种30KDa的I型膜蛋白，具有包含免疫球蛋白(Ig)和高度O-糖基化粘蛋白亚结构域以及多个N-糖基化位点的胞外域。它是损伤肾脏近端小管中最高度上调的蛋白质。它在正常肾脏中以非常低的水平存在，但会在损伤期间上调，在多种疾病的尿液中可检测到。KIM-1可能是肾损伤的生物标志物，这表明它在各种肾脏疾病中具有重要意义，例如慢性肾脏疾病，以及急性肾小管坏死和急性肾衰竭。
Enzo Life Sciences提供的KIM-1 (human) ELISA kit可定量检测人尿液样本中的早期肾损伤生物标志物KIM-1，超高灵敏度，可检测低至1.279 pg/ml的KIM-1。
产品信息
|
产品货号 |
ADI-900-226-0001 |
|
产品名称 |
KIM-1 (human) ELISA kit |
|
规格 |
96 wells |
|
其他名称 |
Kidney injury molecule-1, T-cell immunoglobulin and mucin domain-containing protein 1, TIMD-1, TIM-1, HAVCR1, Hepatitis A virus cellular receptor 1, T-cell immunoglobulin mucin receptor 1, CD365 |
|
灵敏度 |
1.279 pg/ml |
|
检测范围 |
7.813 - 500 pg/ml |
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适用样本类型 |
尿液 |
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适用种属 |
人 |
|
检测时间 |
<2 hours |
|
检测波长 |
450 nm |
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交叉反应 |
No cross reactivity to similar molecules (< 0.02% TIM-3, TIM-4) |
|
试剂盒组分 |
Microtiter Plate, Assay Buffer, Standard, Antibody-conjugate, Streptavidin-HRP, TMB Substrate, Stop Solution, Wash Buffer Concentrate |
标准曲线示例
部分产品文献引用
1. Identification of Pre-Renal and Intrinsic Acute Kidney Injury by Anamnestic and Biochemical Criteria: Distinct Association with Urinary Injury Biomarke: S.M. Sancho-Martínez, et al.; Int. J. Mol. Sci. 24, 1826 (2023)
2. Early Diagnosis of Kidney Damage Associated with Tobacco Use: Preventive Application: J. Tascón, et al.; J. Pers. Med. 12, 1032 (2022)
3. The effect of interval and continuous work on markers of acute kidney injury in a hot environment: J. Houck, et al.; Eur. J. Appl. Physiol. 122, 2437 (2022)
4. The Effects of Beverage Intake after Exhaustive Exercise on Organ Damage, Inflammation and Oxidative Stress in Healthy Males: T. Tominaga, et al.; Antioxidants (Basel) 10, 866 (2021), Application(s): KIM-1 quantification on human urine and plasma samples
5. Biomarkers in the prediction of contrast media induced nephropathy – the BITCOIN study: F.S. Seibert, et al.; PLoS One 15, e0234921 (2020)
6. Designing new diagnostic systems for the early detection of tobacco-associated chronic renal damage in patients of a primary care centre in Salamanca, Spain: an observational, prospective study protocol: M. Prieto, et al.; BMJ Open 10, e032918 (2020)
7. Quercetin, a promising clinical candidate for the prevention of contrast-induced nephropathy: L. Vicente-Vicente, et al.; Int. J. Mol. Sci. 20, 4961 (2019), Application(s): ELISA using human urine
8. Prognostic Value of Urinary Calprotectin, NGAL and KIM-1 in Chronic Kidney Disease: F.S. Seibert, et al.; Kidney Blood Press Res. 43, 1255 (2018)
9. Urinary Biomarkers in the Prediction of Prognosis and Treatment Response in IgA Nephropathy: J. Neuhaus, et al.; Kidney Blood Press Res. 43, 1563 (2018)
10. Hepatic ischemia/reperfusion injury associates with acute kidney injury in liver transplantation: prospective cohort study: I. Jochmans, et al.; Liver Transpl. 23, 634 (2017), Application(s): ELISA using human urine
11. Urinary calprotectin, kidney injury molecule-1, and neutrophil gelatinase-associated lipocalin for the prediction of adverse outcome in pediatric acute kidney injury: J.H. Westhoff, et al.; Eur. J. Pediatr. 176, 745 (2017), Application(s): ELISA using human urine
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